St. Ambrose College of Education was established by the Catholic Diocese of Sunyani on November 21, 2009. St. Ambrose was officially inaugurated on January 21, 2011. The College started with a pioneer class of 238 students and was previously managed by a Board of Trustees (appointed by the Bishop). 

St. Ambrose has now been absorbed by the Government as a Public College of Education and full implementation of the absorption took place in the 2016-2017 academic year.

St. Ambrose College of Education is affiliated to University of Cape Coast.